The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis

The association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis: a meta-analysis

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Shu-Tao Gao,1 Zheng-Tao Lv,2 Wei-Bin Sheng1 1Department of Spine Surgery, The First Affiliate Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China; 2Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Purpose: This study was conducted to assess and synthesize the current evidence on the association between rs12901499 polymorphism in SMAD3 gene and risk of osteoarthritis (OA).Materials and methods: Four electronic databases, including PubMed, Embase, ISI Web of Science, and CENTRAL were systematically searched for potential studies.Summary odds ratio and corresponding 95% CI were calculated to evaluate the association.Risk of bias was Dryer Fan assessed through the Newcastle–Ottawa Scale.Subgroups and sensitivity analyses were performed using the RevMan 5.

3 software.Publication bias was evaluated by Egger’s and Begg’s tests.Power analysis was conducted using the Power and Sample Size Calculation program.Results: Eight case–control studies containing 5,625 patients with OA and 5,600 healthy controls were obtained for the meta-analysis.After excluding cohorts with inadequate power, the pooled data supported that G allele carriers of rs12901499 had a significantly Cards increased risk of OA (odds ratio 1.

31, 95% CI: 1.21 to 1.43, P<0.00001).When stratified by OA site and ethnicity, the association remained statistically significant.

Conclusion: The combined results evidently supported that rs12901499 polymorphism in SMAD3 gene is significantly associated with OA vulnerability across both Caucasian and Asian populations.Keywords: osteoarthritis, polymorphism, SMAD3, rs12901499, meta-analysis.